Dizal (SSE:688192), a biopharmaceutical company committed to developing novel medicines for the treatment of cancer and immunological diseases, announced that the latest data from eight hematologic malignancy clinical trials will be presented at the 2025 European Hematology Association (EHA) Congress and the 18th International Conference on Malignant Lymphoma (ICML). Notably, Dizal’s two investigational drugs in lymphoma—golidocitinib and DZD8586—have collectively secured three oral presentations at the upcoming American Society of Clinical Oncology (ASCO) Annual Meeting, EHA Congress and ICML.
“Golidocitinib and DZD8586 are core assets in our hematologic malignancy pipeline. Accumulating clinical data continue to validate their clinical benefits to patients and attracted community’s attention,” said Xiaolin Zhang, PhD, CEO of Dizal.
A high proportion of PTCL patients who achieved tumor response with first-line standard therapy will relapse. Approximately 40% of patients with complete response (CR) and 80% with partial response (PR) experience disease progression within 2 years after initial tumor response. The prognosis of these relapsed patients is very poor. Currently, there is no standard maintenance therapy available.
The latest 2-year follow-up data from JACKPOT26, a prospective, multicenter Phase II study of golidocitinib, will be presented at both the upcoming EHA Congress and ICML, where it has been selected for an oral presentation. This study explored golidocitinib as a maintenance therapy for peripheral T-cell lymphoma (PTCL) patients who achieved tumor response after first-line systemic therapy. The results showed that with more than 2 years follow-up, golidocitinib continued to demonstrate a promising effect on maintaining and enhancing tumor response in patients with PTCL post first-line therapies, with a manageable safety profile.
Initial positive results of Golidocitinib in combination with CHOP in 1st line PTCL patients will be reported during these meetings. In addition, Dizal will present results for golidocitinib in rare T-cell lymphoma subtypes, including relapsed/refractory T-cell large granular lymphocyte leukemia (r/r T-LGLL), monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL).
Two studies of DZD8586 have been selected for presentation at ASCO, EHA, and ICML. The safety and efficacy analysis of Phase I/II studies of DZD8586 in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) patients with prior treatment using covalent and/or non-covalent BTK inhibitors and BTK degraders has been accepted for oral presentation at both ASCO and ICML. The study results showed DZD8586 exhibited significant anti-tumor activities with well-tolerated safety profile in these heavily pre-treated CLL/SLL patients.
Results of a Phase II study of DZD8586 as monotherapy in relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) will be reported for the first time at the 2025 EHA Congress. DZD8586 showed promising anti-tumor activity and a manageable safety profile.
